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1

[Annual Reports in Medicinal Chemistry] Volume 34 || Chapter 9. Anticoagulants: Thrombin and Factor Xa Inhibitors

Year:

1999

Language:

english

File:

PDF, 1.34 MB

english, 1999

2

Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa1

Pinto, Donald J. P., Orwat, Michael J., Wang, Shuaige, Fevig, John M., Quan, Mimi L., Amparo, Eugene, Cacciola, Joseph, Rossi, Karen A., Alexander, Richard S., Smallwood, Angela M.

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 320 KB

english, 2001

3

Preparation of 1-(3-aminobenzo[d]isoxazol-5-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective, and efficacious inhibitors of coagulation factor Xa

Yun-Long Li, John M. Fevig, Joseph Cacciola, Joseph Buriak Jr., Karen A. Rossi, Janan Jona, Robert M. Knabb, Joseph M. Luettgen, Pancras C. Wong, Stephen A. Bai, Ruth R. Wexler, Patrick Y.S. Lam

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 180 KB

english, 2006

4

An enolate claisen route to c-pyranosides : Development and application to an ionophore synthon

Steven D. Burke, David M. Armistead, Frank J. Schoenen, John M. Fevig

Journal:

Year:

1986

Language:

english

File:

PDF, 1.78 MB

english, 1986

5

Optimization of Activity, Selectivity, and Liability Profiles in 5-Oxopyrrolopyridine DPP4 Inhibitors Leading to Clinical Candidate ( Sa )-2-(3-(Aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5 H -pyrrolo[3,4- b ]pyridin-6(7 H )-yl)- N , N -dimethylacetamide (BMS-767778)

Devasthale, Pratik, Wang, Ying, Wang, Wei, Fevig, John, Feng, JianXin, Wang, Aiying, Harrity, Tom, Egan, Don, Morgan, Nathan, Cap, Michael, Fura, Aberra, Klei, Herbert E., Kish, Kevin, Weigelt, Caroly

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 2.08 MB

english, 2013

6

Synthesis applications of cationic aza-Cope rearrangements. 24. The aza-Cope-Mannich approach to Strychnos alkaloids. Short stereocontrolled total syntheses of (.+-.)-dehydrotubifoline and (.+-.)-akuammicine

Angle, Steven R., Fevig, John M., Knight, Steven D., Marquis, Robert W., Overman, Larry E.

Journal:

Journal of the American Chemical Society

Year:

1993

Language:

english

File:

PDF, 1.44 MB

english, 1993

7

Synthesis and antiplatelet activity of DMP 757 analogs

John Wityak, John M. Fevig, Sharon A. Jackson, Alexander L. Johnson, Shaker A. Mousa, Anju Parthasarathy, Gregory J. Wells, William F. DeGrado, Ruth R. Wexler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 208 KB

english, 1995

8

Structure-Based Design of Novel Guanidine/Benzamidine Mimics: Potent and Orally Bioavailable Factor Xa Inhibitors as Novel Anticoagulants

Lam, Patrick Y. S., Clark, Charles G., Li, Renhua, Pinto, Donald J. P., Orwat, Michael J., Galemmo, Robert A., Fevig, John M., Teleha, Christopher A., Alexander, Richard S., Smallwood, Angela M.

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 402 KB

english, 2003

9

Inhibitors of Acyl CoA:Cholesterol Acyltransferase

Vaccaro, Wayne, Amore, Cindy, Berger, Joel, Burrier, Robert, Clader, John, Davis, Harry, Domalski, Martin, Fevig, Tom, Salisbury, Brian, Sher, Rosy

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 549 KB

english, 1996

10

Synthesis of conformationally-restricted boropeptide thrombin inhibitors

Joseph Cacciola, John M. Fevig, Richard S. Alexander, David R. Brittelli, Charles A. Kettner, Robert M. Knabb, Patricia C. Weber

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 331 KB

english, 1996

11

Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists

Fevig, John M., Feng, Jianxin, Rossi, Karen A., Miller, Keith J., Wu, Ginger, Hung, Chen-Pin, Ung, Thao, Malmstrom, Sarah E., Zhang, Ge, Keim, William J., Cullen, Mary Jane, Rohrbach, Kenneth W., Qu,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 783 KB

english, 2013

12

The Dirty Secret of Primary Sludge Prefermenters

Bratby, John, Fevig, Stephanie, Jimenez, Jose

Journal:

Proceedings of the Water Environment Federation

Year:

2012

Language:

english

File:

PDF, 773 KB

english, 2012

13

ChemInform Abstract: Synthesis and Activity Studies of Conformationally Restricted α-Ketoamide Factor Xa Inhibitors.

Joseph Cacciola, John M. Fevig, Pieter F. W. Stouten, Richard S. Alexander, Robert M. Knabb, Ruth R. Wexler

Journal:

Year:

2000

File:

PDF, 34 KB

2000

14

ChemInform Abstract: Preparation of Pyrrolidine and Isoxazolidine Benzamidines as Potent Inhibitors of Coagulation Factor Xa.

John M. Fevig, Joseph Buriak Jr., Pieter F. W. Stouten, Robert M. Knabb, Gilbert N. Lam, Pancras C. Wong, Ruth R. Wexler

Journal:

Year:

1999

File:

PDF, 34 KB

1999

15

ChemInform Abstract: Preparation of meta-Amidino-N,N-disubstituted Anilines as Potent Inhibitors of Coagulation Factor Xa.

John M. Fevig, Joseph Cacciola, Richard S. Alexander, Robert M. Knabb, Gilbert N. Lam, Pancras C. Wong, Ruth R. Wexler

Journal:

Year:

1999

File:

PDF, 32 KB

1999

16

Preparation of pyrrolidine and isoxazolidine benzamidines as potent inhibitors of coagulation factor Xa

John M. Fevig, Joseph Buriak Jr., Pieter F.W. Stouten, Robert M. Knabb, Gilbert N. Lam, Pancras C. Wong, Ruth R. Wexler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 361 KB

english, 1999

17

Rational design of boropeptide thrombin inhibitors: β,β-dialkyl-phenethylglycine P2 analogs of DuP 714 with greater selectivity over complement factor I and an improved safety profile

John M Fevig, Joseph Buriak Jr., Joseph Cacciola, Richard S Alexander, Charles A Kettner, Robert M Knabb, James R Pruitt, Patricia C Weber, Ruth R Wexler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 403 KB

english, 1998

18

Estrogen receptor binding tolerance of 16α-substituted estradiol derivatives

Thomas L. Fevig, Michael K. Mao, John A. Katzenellenbogen

Journal:

Year:

1988

Language:

english

File:

PDF, 1.57 MB

english, 1988

19

Encyclopedia of Reagents for Organic Synthesis || N -Morpholinomethyldiphenylphosphine Oxide

Year:

2001

Language:

english

File:

PDF, 55 KB

english, 2001

20

Aminobenzisoxazoles with biaryl P4 moieties as potent, selective, and orally bioavailable factor Xa inhibitors

Mimi L. Quan, Qi Han, John M. Fevig, Patrick Y.S. Lam, Steve Bai, Robert M. Knabb, Joseph M. Luettgen, Pancras C. Wong, Ruth R. Wexler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 117 KB

english, 2006

21

Preparation of 1-(4-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective and bioavailable inhibitors of coagulation factor Xa

John M. Fevig, Joseph Cacciola, Joseph Buriak Jr., Karen A. Rossi, Robert M. Knabb, Joseph M. Luettgen, Pancras C. Wong, Stephen A. Bai, Ruth R. Wexler, Patrick Y.S. Lam

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 166 KB

english, 2006

22

Encyclopedia of Reagents for Organic Synthesis || Trimethyl Phosphate

Year:

2001

Language:

english

File:

PDF, 52 KB

english, 2001

23

Design and synthesis of ring-constrained boropeptide thrombin inhibitors

John M. Fevig, Matthew M. Abelman, David R. Brittelli, Charles A. Kettner, Robert M. Knabb, Patricia C. Weber

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 323 KB

english, 1996

24

New approach to Strychnos alkaloids. Stereocontrolled total synthesis of (.+-.)-dehydrotubifoline

Fevig, John M., Marquis, Robert W., Overman, Larry E.

Journal:

Journal of the American Chemical Society

Year:

1991

Language:

english

File:

PDF, 270 KB

english, 1991

25

The synthesis of lysine α-ketoamide thrombin inhibitord via an epoxy amide ring opening

Joseph Cacciola, Richard S Alexander, John M Fevig, Pieter F.W Stouten

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 185 KB

english, 1997

26

Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core

John M. Fevig, Donald J. Pinto, Qi Han, Mimi L. Quan, James R. Pruitt, Irina C. Jacobson, Robert A. Galemmo, Jr, Shuaige Wang, Michael J. Orwat, Lori L. Bostrom, Robert M. Knabb, Pancras C. Wong, Patr

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 222 KB

english, 2001

27

Centrate Equalization – What You Don't Control Can Hurt You

Fevig, Stephanie, Bratby, John, Douville, Chris, Farmer, Greg

Journal:

Proceedings of the Water Environment Federation

Year:

2011

Language:

english

File:

PDF, 2.22 MB

english, 2011

28

Ionophore synthesis. An enantioselective route to the left-wing of indanomycin (X- 14547A).

Steven D. Burke, David M. Armistead, John M. Fevig

Journal:

Tetrahedron Letters

Year:

1985

Language:

english

File:

PDF, 218 KB

english, 1985

29

Preparation, receptor binding, and fluorescence properties of hexestrol-fluorophore conjugates: evaluation of site of attachment, fluorophore structure, and fluorophore-ligand spacing

Fevig, Thomas L., Lloyd, John E., Zablocki, Jeffery A., Katzenellenbogen, John A.

Journal:

Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 1.26 MB

english, 1987

30

Nitrification in one week without external seeding — Startup of a new BNR plant

Bratby, John, Fevig, Stephanie, Douville, Chris, Freeman, Dan, Oram, Ernie, Parker, Denny

Journal:

Proceedings of the Water Environment Federation

Year:

2008

Language:

english

File:

PDF, 702 KB

english, 2008

31

ChemInform Abstract: Synthesis and SAR of Benzamidine Factor Xa Inhibitors Containing a Vicinally-Substituted Heterocyclic Core.

John M. Fevig, Donald J. Pinto, et al. et al.

Journal:

Year:

2001

File:

PDF, 28 KB

2001

32

Preparation of meta-amidino-N,N-disubstituted anilines as potent inhibitors of coagulation factor Xa

John M. Fevig, Joseph Cacciola, Richard S. Alexander, Robert M. Knabb, Gilbert N. Lam, Pancras C. Wong, Ruth R. Wexler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 354 KB

english, 1998

33

Am I Sampling Too Little, or Too Much? A Template to Guide Utilities on Appropriate Sampling Requirements

Bratby, John, Fevig, Stephanie

Journal:

Proceedings of the Water Environment Federation

Year:

2011

Language:

english

File:

PDF, 567 KB

english, 2011

34

The 2007 Sludge Thickening Adventure in Boulder, Colorado

Fevig, Stephanie, Bratby, John, Douville, Chris, Heppler, Paul

Journal:

Proceedings of the Water Environment Federation

Year:

2008

Language:

english

File:

PDF, 558 KB

english, 2008

35

Synthesis and activity studies of conformationally restricted α-ketoamide factor Xa inhibitors

Joseph Cacciola, John M. Fevig, Pieter F.W. Stouten, Richard S. Alexander, Robert M. Knabb, Ruth R. Wexler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 498 KB

english, 2000

36

(N-acyl-N-alkyl)glycyl borolysine analogs: A new class of potent thrombin inhibitors

Robert A. Galemmo Jr., John M. Fevig, David J. Carini, Joseph Cacciola, Brian L. Wells, Gregory L. Hillyer, Joseph Buriak Jr., Karen A. Rossi, Pieter F.W. Stouten, Richard S. Alexander, Richard Hilmer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 372 KB

english, 1996

37

A short, stereoselective route to 16.alpha.-(substituted-alkyl)estradiol derivatives

Fevig, Thomas L., Katzenellenbogen, John A.

Journal:

Journal of Organic Chemistry

Year:

1987

Language:

english

File:

PDF, 661 KB

english, 1987

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